AustralieFrV1, Main, Exploration, bibRecord, 001571

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Identifieur interne : 001571 ( Main/Exploration ); précédent : 001570; suivant : 001572

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

Auteurs : Leora Witkowski [Canada] ; Catherine Goudie [Canada] ; Pilar Ramos [États-Unis] ; Talia Boshari [Canada] ; Jean-Sebastien Brunet [Canada] ; Anthony N. Karnezis [Canada] ; Michel Longy [France] ; James A. Knost [États-Unis] ; Emmanouil Saloustros [Grèce] ; W Glenn Mccluggage [Royaume-Uni] ; Colin J R. Stewart [Australie] ; William P D. Hendricks [États-Unis] ; Heather Cunliffe [Nouvelle-Zélande] ; David G. Huntsman [Canada] ; Patricia Pautier [France] ; Douglas A. Levine [États-Unis] ; Jeffrey M. Trent [États-Unis] ; Andrew Berchuck [États-Unis] ; Martin Hasselblatt [Allemagne] ; William D. Foulkes [Canada]

Source :

Gynecologic oncology [ 1095-6859 ] ; 2016.

RBID : pubmed:26975901

Descripteurs français

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Carcinoma, Small Cell (genetics), Carcinoma, Small Cell (pathology), Carcinoma, Small Cell (therapy), Child, Cohort Studies, DNA Helicases (genetics), Female, Germ-Line Mutation, Humans, Hypercalcemia (genetics), Hypercalcemia (pathology), Hypercalcemia (therapy), Kaplan-Meier Estimate, Neoplasm Staging, Nuclear Proteins (genetics), Ovarian Neoplasms (genetics), Ovarian Neoplasms (pathology), Ovarian Neoplasms (therapy), Prognosis, Transcription Factors (genetics), Young Adult.
MESH :
- chemical , genetics : DNA Helicases, Nuclear Proteins, Transcription Factors.
- genetics : Carcinoma, Small Cell, Hypercalcemia, Ovarian Neoplasms.
- pathology : Carcinoma, Small Cell, Hypercalcemia, Ovarian Neoplasms.
- therapy : Carcinoma, Small Cell, Hypercalcemia, Ovarian Neoplasms.
- Adolescent, Adult, Age Factors, Child, Cohort Studies, Female, Germ-Line Mutation, Humans, Kaplan-Meier Estimate, Neoplasm Staging, Prognosis, Young Adult.

Abstract

Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor, with long term survival at ~30% in early stage disease. SCCOHT is caused by germline and somatic SMARCA4 mutations, but the effect of the mutation type on patients remains unknown. Furthermore, the rarity of SCCOHT has resulted in varied treatment, with no standardized protocols. We analyzed 293 cases to determine the effect of treatment modalities and SMARCA4 mutations on patient diagnosis and outcome.

DOI: 10.1016/j.ygyno.2016.03.013
PubMed: 26975901

Affiliations:

Le document en format XML

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<author><name sortKey="Saloustros, Emmanouil" sort="Saloustros, Emmanouil" uniqKey="Saloustros E" first="Emmanouil" last="Saloustros">Emmanouil Saloustros</name>
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<author><name sortKey="Stewart, Colin J R" sort="Stewart, Colin J R" uniqKey="Stewart C" first="Colin J R" last="Stewart">Colin J R. Stewart</name>
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<author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M" last="Trent">Jeffrey M. Trent</name>
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<author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name>
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<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.</title>
<author><name sortKey="Witkowski, Leora" sort="Witkowski, Leora" uniqKey="Witkowski L" first="Leora" last="Witkowski">Leora Witkowski</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, QC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC</wicri:regionArea>
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<author><name sortKey="Goudie, Catherine" sort="Goudie, Catherine" uniqKey="Goudie C" first="Catherine" last="Goudie">Catherine Goudie</name>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Pediatrics, McGill University, Montreal, QC</wicri:regionArea>
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<author><name sortKey="Ramos, Pilar" sort="Ramos, Pilar" uniqKey="Ramos P" first="Pilar" last="Ramos">Pilar Ramos</name>
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</placeName>
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<author><name sortKey="Boshari, Talia" sort="Boshari, Talia" uniqKey="Boshari T" first="Talia" last="Boshari">Talia Boshari</name>
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<author><name sortKey="Brunet, Jean Sebastien" sort="Brunet, Jean Sebastien" uniqKey="Brunet J" first="Jean-Sebastien" last="Brunet">Jean-Sebastien Brunet</name>
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<author><name sortKey="Karnezis, Anthony N" sort="Karnezis, Anthony N" uniqKey="Karnezis A" first="Anthony N" last="Karnezis">Anthony N. Karnezis</name>
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<author><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name>
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<author><name sortKey="Knost, James A" sort="Knost, James A" uniqKey="Knost J" first="James A" last="Knost">James A. Knost</name>
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</placeName>
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<author><name sortKey="Saloustros, Emmanouil" sort="Saloustros, Emmanouil" uniqKey="Saloustros E" first="Emmanouil" last="Saloustros">Emmanouil Saloustros</name>
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<author><name sortKey="Mccluggage, W Glenn" sort="Mccluggage, W Glenn" uniqKey="Mccluggage W" first="W Glenn" last="Mccluggage">W Glenn Mccluggage</name>
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</affiliation>
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<author><name sortKey="Stewart, Colin J R" sort="Stewart, Colin J R" uniqKey="Stewart C" first="Colin J R" last="Stewart">Colin J R. Stewart</name>
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<wicri:noRegion>Perth</wicri:noRegion>
</affiliation>
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<author><name sortKey="Hendricks, William P D" sort="Hendricks, William P D" uniqKey="Hendricks W" first="William P D" last="Hendricks">William P D. Hendricks</name>
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<country xml:lang="fr">États-Unis</country>
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<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cunliffe, Heather" sort="Cunliffe, Heather" uniqKey="Cunliffe H" first="Heather" last="Cunliffe">Heather Cunliffe</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.</nlm:affiliation>
<country xml:lang="fr">Nouvelle-Zélande</country>
<wicri:regionArea>Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin</wicri:regionArea>
<wicri:noRegion>Dunedin</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huntsman, David G" sort="Huntsman, David G" uniqKey="Huntsman D" first="David G" last="Huntsman">David G. Huntsman</name>
<affiliation wicri:level="1"><nlm:affiliation>BC Cancer Agency, Vancouver, BC, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>BC Cancer Agency, Vancouver, BC</wicri:regionArea>
<wicri:noRegion>BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Pautier, Patricia" sort="Pautier, Patricia" uniqKey="Pautier P" first="Patricia" last="Pautier">Patricia Pautier</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Gustave Roussy, Villejuif, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Medical Oncology, Gustave Roussy, Villejuif</wicri:regionArea>
<wicri:noRegion>Villejuif</wicri:noRegion>
<wicri:noRegion>Villejuif</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A" last="Levine">Douglas A. Levine</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Surgery, Memorial Sloan Kettering Cancer Center, NY, New York, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Surgery, Memorial Sloan Kettering Cancer Center, NY, New York</wicri:regionArea>
<placeName><region type="state">État de New York</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M" last="Trent">Jeffrey M. Trent</name>
<affiliation wicri:level="2"><nlm:affiliation>Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Integrated Cancer Genomics Division, Translational Genomics Research Institute, Phoenix, AZ</wicri:regionArea>
<placeName><region type="state">Arizona</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name>
<affiliation wicri:level="2"><nlm:affiliation>Duke University Medical Center, Durham, NC, USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Duke University Medical Center, Durham, NC</wicri:regionArea>
<placeName><region type="state">Caroline du Nord</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
<affiliation wicri:level="3"><nlm:affiliation>Institute of Neuropathology, University Hospital Münster, Münster, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Neuropathology, University Hospital Münster, Münster</wicri:regionArea>
<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Münster</region>
<settlement type="city">Münster</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, QC, Canada; Department of Medical Genetics and Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC, Canada. Electronic address: William.foulkes@mcgill.ca.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Human Genetics, McGill University, Montreal, QC, Canada; Lady Davis Institute and Segal Cancer Center, Jewish General Hospital, Montreal, QC, Canada; Department of Medical Genetics and Cancer Research Program, Research Institute, McGill University Health Centre, Montreal, QC</wicri:regionArea>
<orgName type="university">Université McGill</orgName>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Gynecologic oncology</title>
<idno type="eISSN">1095-6859</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Carcinoma, Small Cell (genetics)</term>
<term>Carcinoma, Small Cell (pathology)</term>
<term>Carcinoma, Small Cell (therapy)</term>
<term>Child</term>
<term>Cohort Studies</term>
<term>DNA Helicases (genetics)</term>
<term>Female</term>
<term>Germ-Line Mutation</term>
<term>Humans</term>
<term>Hypercalcemia (genetics)</term>
<term>Hypercalcemia (pathology)</term>
<term>Hypercalcemia (therapy)</term>
<term>Kaplan-Meier Estimate</term>
<term>Neoplasm Staging</term>
<term>Nuclear Proteins (genetics)</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Ovarian Neoplasms (pathology)</term>
<term>Ovarian Neoplasms (therapy)</term>
<term>Prognosis</term>
<term>Transcription Factors (genetics)</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Carcinome à petites cellules ()</term>
<term>Carcinome à petites cellules (anatomopathologie)</term>
<term>Carcinome à petites cellules (génétique)</term>
<term>Enfant</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de l'âge</term>
<term>Facteurs de transcription (génétique)</term>
<term>Femelle</term>
<term>Helicase (génétique)</term>
<term>Humains</term>
<term>Hypercalcémie ()</term>
<term>Hypercalcémie (anatomopathologie)</term>
<term>Hypercalcémie (génétique)</term>
<term>Jeune adulte</term>
<term>Mutation germinale</term>
<term>Pronostic</term>
<term>Protéines nucléaires (génétique)</term>
<term>Stade de la tumeur</term>
<term>Tumeurs de l'ovaire ()</term>
<term>Tumeurs de l'ovaire (anatomopathologie)</term>
<term>Tumeurs de l'ovaire (génétique)</term>
<term>Études de cohortes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA Helicases</term>
<term>Nuclear Proteins</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome à petites cellules</term>
<term>Hypercalcémie</term>
<term>Tumeurs de l'ovaire</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinoma, Small Cell</term>
<term>Hypercalcemia</term>
<term>Ovarian Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Carcinome à petites cellules</term>
<term>Facteurs de transcription</term>
<term>Helicase</term>
<term>Hypercalcémie</term>
<term>Protéines nucléaires</term>
<term>Tumeurs de l'ovaire</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Small Cell</term>
<term>Hypercalcemia</term>
<term>Ovarian Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Carcinoma, Small Cell</term>
<term>Hypercalcemia</term>
<term>Ovarian Neoplasms</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Child</term>
<term>Cohort Studies</term>
<term>Female</term>
<term>Germ-Line Mutation</term>
<term>Humans</term>
<term>Kaplan-Meier Estimate</term>
<term>Neoplasm Staging</term>
<term>Prognosis</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Carcinome à petites cellules</term>
<term>Enfant</term>
<term>Estimation de Kaplan-Meier</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hypercalcémie</term>
<term>Jeune adulte</term>
<term>Mutation germinale</term>
<term>Pronostic</term>
<term>Stade de la tumeur</term>
<term>Tumeurs de l'ovaire</term>
<term>Études de cohortes</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is an aggressive tumor, with long term survival at ~30% in early stage disease. SCCOHT is caused by germline and somatic SMARCA4 mutations, but the effect of the mutation type on patients remains unknown. Furthermore, the rarity of SCCOHT has resulted in varied treatment, with no standardized protocols. We analyzed 293 cases to determine the effect of treatment modalities and SMARCA4 mutations on patient diagnosis and outcome.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Australie</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Nouvelle-Zélande</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Arizona</li>
<li>Caroline du Nord</li>
<li>District de Münster</li>
<li>Illinois</li>
<li>Nouvelle-Aquitaine</li>
<li>Québec</li>
<li>Rhénanie-du-Nord-Westphalie</li>
<li>État de New York</li>
</region>
<settlement><li>Bordeaux</li>
<li>Montréal</li>
<li>Münster</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université de Bordeaux</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Québec"><name sortKey="Witkowski, Leora" sort="Witkowski, Leora" uniqKey="Witkowski L" first="Leora" last="Witkowski">Leora Witkowski</name>
</region>
<name sortKey="Boshari, Talia" sort="Boshari, Talia" uniqKey="Boshari T" first="Talia" last="Boshari">Talia Boshari</name>
<name sortKey="Brunet, Jean Sebastien" sort="Brunet, Jean Sebastien" uniqKey="Brunet J" first="Jean-Sebastien" last="Brunet">Jean-Sebastien Brunet</name>
<name sortKey="Foulkes, William D" sort="Foulkes, William D" uniqKey="Foulkes W" first="William D" last="Foulkes">William D. Foulkes</name>
<name sortKey="Goudie, Catherine" sort="Goudie, Catherine" uniqKey="Goudie C" first="Catherine" last="Goudie">Catherine Goudie</name>
<name sortKey="Huntsman, David G" sort="Huntsman, David G" uniqKey="Huntsman D" first="David G" last="Huntsman">David G. Huntsman</name>
<name sortKey="Karnezis, Anthony N" sort="Karnezis, Anthony N" uniqKey="Karnezis A" first="Anthony N" last="Karnezis">Anthony N. Karnezis</name>
</country>
<country name="États-Unis"><region name="Arizona"><name sortKey="Ramos, Pilar" sort="Ramos, Pilar" uniqKey="Ramos P" first="Pilar" last="Ramos">Pilar Ramos</name>
</region>
<name sortKey="Berchuck, Andrew" sort="Berchuck, Andrew" uniqKey="Berchuck A" first="Andrew" last="Berchuck">Andrew Berchuck</name>
<name sortKey="Hendricks, William P D" sort="Hendricks, William P D" uniqKey="Hendricks W" first="William P D" last="Hendricks">William P D. Hendricks</name>
<name sortKey="Knost, James A" sort="Knost, James A" uniqKey="Knost J" first="James A" last="Knost">James A. Knost</name>
<name sortKey="Levine, Douglas A" sort="Levine, Douglas A" uniqKey="Levine D" first="Douglas A" last="Levine">Douglas A. Levine</name>
<name sortKey="Trent, Jeffrey M" sort="Trent, Jeffrey M" uniqKey="Trent J" first="Jeffrey M" last="Trent">Jeffrey M. Trent</name>
</country>
<country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Longy, Michel" sort="Longy, Michel" uniqKey="Longy M" first="Michel" last="Longy">Michel Longy</name>
</region>
<name sortKey="Pautier, Patricia" sort="Pautier, Patricia" uniqKey="Pautier P" first="Patricia" last="Pautier">Patricia Pautier</name>
</country>
<country name="Grèce"><noRegion><name sortKey="Saloustros, Emmanouil" sort="Saloustros, Emmanouil" uniqKey="Saloustros E" first="Emmanouil" last="Saloustros">Emmanouil Saloustros</name>
</noRegion>
</country>
<country name="Royaume-Uni"><noRegion><name sortKey="Mccluggage, W Glenn" sort="Mccluggage, W Glenn" uniqKey="Mccluggage W" first="W Glenn" last="Mccluggage">W Glenn Mccluggage</name>
</noRegion>
</country>
<country name="Australie"><noRegion><name sortKey="Stewart, Colin J R" sort="Stewart, Colin J R" uniqKey="Stewart C" first="Colin J R" last="Stewart">Colin J R. Stewart</name>
</noRegion>
</country>
<country name="Nouvelle-Zélande"><noRegion><name sortKey="Cunliffe, Heather" sort="Cunliffe, Heather" uniqKey="Cunliffe H" first="Heather" last="Cunliffe">Heather Cunliffe</name>
</noRegion>
</country>
<country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Hasselblatt, Martin" sort="Hasselblatt, Martin" uniqKey="Hasselblatt M" first="Martin" last="Hasselblatt">Martin Hasselblatt</name>
</region>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

The influence of clinical and genetic factors on patient outcome in small cell carcinoma of the ovary, hypercalcemic type.

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